JCCVS

Journal of Cardiology & Cardiovascular Surgery scientific, open-access, double-blind peer-reviewed journal covering a wide spectrum of topics in cardiology and cardiovascular surgery. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

EndNote Style
Index
Original Article
The effect of anxiety on metabolic parameters in patients with primary hypertension
Aims: Although the role of anxiety in the pathogenesis of hypertension is known, the effect of anxiety on metabolic parameters in hypertension has not been demonstrated. This study aimed to evaluate the effect of anxiety on metabolic parameters and blood pressure regulation in patients with primary hypertension.
Methods: The study was designed as a single-center, descriptive cross-sectional study. A total of 150 patients receiving antihypertensive therapy for primary hypertension were included in the study. Patients were divided into minimal, mild, moderate, and severe anxiety groups according to the Beck Anxiety Inventory. Anthropometric measurements, metabolic parameters, and blood pressure measurements were compared between groups.
Results: Significant positive correlations were found between anxiety severity and total cholesterol, LDL cholesterol, body mass index, and waist circumference (p<0.05). Subgroup analyses showed that total cholesterol, LDL cholesterol, body mass index, and waist circumference were higher in the severe anxiety group than in the minimal anxiety group (p<0.05).
Conclusion: Anxiety in patients with primary hypertension appears to have negative consequences on total cholesterol, LDL cholesterol, body mass index, and waist circumference. In hypertension, female gender and obesity are associated with increased anxiety levels.


1. Barquera S, Pedroza-Tob&iacute;as A, Medina C, et al. Global Overview of theEpidemiology of Atherosclerotic Cardiovascular Disease. Arch MedRes. 2015;46(5):328-338. doi:10.1016/j. arcmed.2015.06.006
2. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines forthe management of arterial hypertension. Eur Heart J. 2018;39(33):3021-3104. doi:10.1093/eurheartj/ehy339
3. Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guidelineon the Management of Blood Cholesterol: Executive Summary: AReport of the American College of Cardiology/American HeartAssociation Task Force on Clinical Practice Guidelines. J Am CollCardiol. 2019;73(24):3168-3209. doi:10.1016/j.jacc.2018.11.002
4. Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolicsyndrome: a joint interim statement of the International DiabetesFederation Task Force on Epidemiology and Prevention; NationalHeart, Lung, and Blood Institute; American Heart Association;World Heart Federation; International Atherosclerosis Society;and International Association for the Study of Obesity. Circulation.2009;120(16):1640-1645. doi:10.1161/CIRCULATIONAHA.109.192644
5. Celano CM, Daunis DJ, Lokko HN, Campbell KA, Huffman JC.Anxiety disorders and cardiovascular disease. Curr Psychiatry Rep.2016;18(11):101. doi:10.1007/s11920-016-0739-5
6. Kessler RC, Chiu WT, Demler O, et al. Prevalence, severity, andcomorbidity of 12-month DSM-IV disorders in the NationalComorbidity Survey Replication. Arch Gen Psychiatry. 2015; 140(3):816-845.
7. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, WaltersEE. Lifetime prevalence and age-of-onset distributions of DSM-IVdisorders in the National Comorbidity Survey Replication. Archives ofGeneral Psychiatry. 2005;62(6):593-602.
8. Goossens L, Braet C, Van Vlierberghe L, Mels S. Loss of control overeating in overweight youngsters: the role of anxiety, depression andemotional eating. Eur Eat Disord Rev. 2009; 17(1):68-78. doi:10.1002/erv.892
9. Klatzkin RR, Gaffney S, Cyrus K, Bigus E, Brownley KA. Stress-induced eating in women with binge-eating disorder and obesity. BiolPsychol. 2018;131:96-106. doi:10.1016/j.biopsycho.2016. 11.002
10. Black DW, Goldstein RB, Mason EE. Prevalence of mental disorderin 88 morbidly obese bariatric clinic patients. Am J Psychiatry.1992;149(2):227-234. doi:10.1176/ajp.149.2.227
11. Davies SJ, Ghahramani P, Jackson PR, Hippisley-Cox J, Yeo WW,Ramsay LE. Panic disorder, anxiety and depression in resistanthypertension--a case-control study. J Hypertens. 1997;15(10): 1077-1082. doi:10.1097/00004872-199715100-00005
12. Kaplan NM. Anxiety-induced hyperventilation. A common causeof symptoms in patients with hypertension. Arch Intern Med.1997;157(9):945-948. doi:10.1001/archinte.157.9.945
13. Katon W. Panic disorder and somatization. Review of 55 cases. Am JMed. 1984;77(1):101-106. doi:10.1016/0002-9343(84)90443-1
14. Davies SJ, Ghahramani P, Jackson PR, et al. Association ofpanic disorder and panic attacks with hypertension. Am J Med.1999;107(4):310-316. doi:10.1016/s0002-9343(99)00237-5
15. Bajwa WK, Asnis GM, Sanderson WC, Irfan A, van Praag HM. Highcholesterol levels in patients with panic disorder. Am J Psychiatry.1992;149(3):376-378. doi:10.1176/ajp.149.3.376
16. Ware WR. High cholesterol and coronary heart disease in youngermen: the potential role of stress induced exaggerated blood pressureresponse. Med Hypotheses. 2008;70(3):543-547. doi:10. 1016/j.mehy.2007.06.031
17. Dreyfuss F, Czaczkes JW. Blood cholesterol and uric acidof healthy medical students under the stress of an examination.AMA Arch Intern Med. 1959;103(5):708-711. doi:10.1001/archinte.1959.00270050030006
18. Stoney CM, Niaura R, Bausserman L, Matacin M. Lipid reactivityto stress: I. Comparison of chronic and acute stress responses inmiddle-aged airline pilots. Health Psychol. 1999;18(3):241-250.doi:10.1037//0278-6133.18.3.241
19. Kuczmierczyk AR, Barbee JG, Bologna NA, Townsend MH. Serumcholesterol levels in patients with generalized anxiety disorder (GAD)and with GAD and comorbid major depression. Can J Psychiatry.1996;41(7):465-468. doi:10.1177/070674379604100712
20. Kessler RC, Keller MB, Wittchen HU. The epidemiology of generalizedanxiety disorder. Psychiatr Clin North Am. 2001;24(1):19-39.doi:10.1016/s0193-953x(05)70204-5
21. Siafis S, Tzachanis D, Samara M, Papazisis G. Antipsychoticdrugs: from receptor-binding profiles to metabolic side effects.Curr Neuropharmacol. 2018;16(8):1210-1223. doi:10.2174/1570159X15666170630163616
22. Beyazy&uuml;z M, Albayrak Y, Eğilmez OB, Albayrak N, Beyazy&uuml;z E.Relationship between SSRIs and metabolic syndrome abnormalitiesin patients with generalized anxiety disorder: a prospective study.Psychiatry Investig. 2013;10(2):148-154. doi:10.4306/pi.2013.10.2.148
23. Girgis RR, Javitch JA, Lieberman JA. Antipsychotic drug mechanisms:links between therapeutic effects, metabolic side effects and the insulinsignaling pathway. Mol Psychiatry. 2008;13(10):918-929. doi:10.1038/mp.2008.40
24. Girault EM, Alkemade A, Foppen E, Ackermans MT, Fliers E, KalsbeekA. Acute peripheral but not central administration of olanzapineinduces hyperglycemia associated with hepatic and extra-hepaticinsulin resistance. PLoS One. 2012;7(8):e43244. doi:10.1371/journal.pone.0043244
25. Albaugh VL, Vary TC, Ilkayeva O, et al. Atypical antipsychoticsrapidly and inappropriately switch peripheral fuel utilization tolipids, impairing metabolic flexibility in rodents. Schizophr Bull.2012;38(1):153-166. doi:10.1093/schbul/sbq053
26. Raeder MB, Bjelland I, Emil Vollset S, Steen VM. Obesity, dyslipidemia,and diabetes with selective serotonin reuptake inhibitors: theHordaland Health Study. J Clin Psychiatry. 2006; 67(12):1974-1982.doi:10.4088/jcp.v67n1219
Volume 2, Issue 3, 2024
Page : 42-47
_Footer