JCCVS
Journal of Cardiology & Cardiovascular Surgery

Journal of Cardiology & Cardiovascular Surgery scientific, open-access, double-blind peer-reviewed journal covering a wide spectrum of topics in cardiology and cardiovascular surgery.

eISSN: 2980-1397
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Original Article
Investigation of serum copeptin levels in patients with congestive heart failure
Abstract
Aims: Congestive heart failure (CHF) is characterized by symptoms and signs of volume overload and tissue perfusion insufficiency and accompanied by neurohormonal activation. Copeptin is a part of pre-pro-vasopressin and synthesized in equal molar amounts with vasopressin. We aimed to evaluate the sensitivity and specificity of copeptin in indicating the diagnostic value of CHF
Methods: This retrospective study included a total of 80 patients including 40 with heart failure and 40 healthy individuals. The groups were compared in terms of demographic features, laboratory findings including copeptin levels.
Results: There was no statistically significant difference between the groups in terms of gender (p>0.05). Age, hypertension, diabetes mellitus, smoking were statistically significantly higher in the heart failure group compared to the control group (p<0.05). In both groups, serum copeptin levels were higher in men than in women. Copeptin levels in the heart failure group were statistically significantly higher than in the control group (p<0.05). In the heart failure group, there was a negative correlation between serum copeptin levels and age, gender, hypertension, smoking, HDL cholesterol, hematocrit, creatinine levels.
Conclusion: Copeptin is a good indicator of the course of the disease in patients with heart failure.

Keywords : Congestive heart failure, copeptin, neurohormonal activation

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Article available in :
Volume 2, Issue 2, 2024
Page : 27-30
https://doi.org/10.51271/JCCVS-0030
Article Information
Received : 10 Haz 2024
Accepted : 26 Haz 2024
Published : 29 Haz 2024
Corresponding Author :

Zülfiye Kuzu: Department of Cardiology, Kayseri City Hospital, Kayseri, Turkiye

[email protected]
Citation : Kuzu Z, Kaya OK, Akgün AN, Solmaz H, Karataş M, Yavuzkır MF. Investigation of serum copeptin levels in patients with congestive heart failure. J Cardiol Cardiovasc Surg. 2024;2(2):27-30.

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